师资队伍
副教授
李汉卿
编辑:必赢亚州,必赢贵宾会 发布时间:2019-12-30 来源:生命科学学院

李汉卿,男,副教授,硕士生导师。

教育经历:华东理工大学本科, 山西大学研究生班毕业。

工作经历

1997.4-至今:  生命科学学院,食品科学与工程系,副教授

1993.9-1997.4: 生命科学学院,讲师

1986.7-1993.9:生命科学学院,助教

参与在研项目

1.山西省应用基础研究计划重点项目,PKM2介导的自噬调控肿瘤耐药的分子机制及抗肿瘤耐药的药物筛选(201801D111001),2018.12-2020.12, 30万元,在研;

2.山西省基础研究计划项目,基于PKM2靶点的沙棘结合态多酚抗肿瘤活性成分及分子机制研究(201801D11101),2018.12-2020.12, 15万元,在研;

3.国家自然科学基金青年基金项目,沙棘叶结合态多酚通过调控PKM选择性剪接抑制Warburg效应的抗肿瘤活性成分及作用机制(31800290),2019.01-2021.12,25万元,在研;

4.国家自然科学基金面上项目,谷糠结合态多酚通过miRNA-149逆转结肠癌多药耐药的活性成分及分子机制(31770382),2018.01-2021.12,60万元,在研。

代表性论文

1. 李汉卿,刘丰铭,单树花,鲁洋,张晓莉,李卓玉。酸枣自由态和结合态多酚对人主动脉平滑肌细胞表型转化的影响。食品科学,2019,40(13):116-122。一级学科主学报

2. Xiaoqin La, Lichao Zhang, Zhuoyu Li*, Hanqing Li, Yufei Yang. (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway,  Journal of Agricultural and Food Chemistry . 2019,67(9):2510–2518. IF 3.571

3. Xiaoli Zhang, Shuhua Shan, Hanqing Li, Jiangying Shi, Yang Lu, Zhuoyu Li*. Cloning, expression of the truncation of recombinant peroxidase derived from millet bran and its reversal effects on 5-Fu resistance in colorectal cancer.  International Journal of Biological Macromolecules . 2019, 19:132:871-879. IF 4.784

4. Yufei Yang, Lichao Zhang, Xiaoqin La, Zhuoyu Li*, Hanqing Li. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion,  Naunyn-Schmiedeberg's Archives of Pharmacology , 2018,392(4):467-480. IF:2.058

5. Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, Zhuoyu Li*. Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell.  Journal of Agricultural and Food Chemistry .  2018, 66, 5190-5199. IF 3.571

6. Haili Wu, Yingying Wang, Changxin Wu, Peng Yang, Hanqing Li, Zhuoyu Li*. Resveratrol induced cancer cell apoptosis through miR-326/PKM2 mediated ER stress and mitochondrial fission.  Journal of Agricultural and Food Chemistry . 2016, 64 (49): 9356-9367. IF: 3.571

7. Haili Wu, Yingying Wang, Peng Yang, Zongrui Li, Hanqing Li, Changxin Wu, Zhuoyu Li*. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.  American Journal of Cancer Research. 2016, 6 (10): 2221-2234. IF: 4.737

8.  Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells.  BMC  B  iotechnology . 2016, 16(1): 1-13. IF: 2.303

9. Min Guo, GuoBin Ding, Peng Yang, Lichao Zhang, Haili Wu, Hanqing Li, Zhuoyu Li*. Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher.  Journal of Agricultural and Food Chemistry .  2016, 64, 6277-6285. IF 3.571

国家发明专利

1. 一种靶向抗肿瘤活性蛋白及其制备与纯化(2019), CN105199000B,李卓玉,张立超,李宗伟,史通麟,杨鹏,李汉卿;

2. 谷糠源过氧化物酶抗肿瘤活性片段及其制备方法和应用(2018), CN201810027037.1,单树花、张晓莉、李卓玉、李汉卿、武海丽、史江颖;

3. 一种酸枣仁抗肿瘤结合态多酚及其制备方法和应用(2018),CN201810038716.9,单树花、解悦、李卓玉、李汉卿、郭松佳、鲁洋、张晓莉。

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