师资队伍
副教授
落继先
编辑:必赢亚州,必赢贵宾会 发布时间:2019-12-30 来源:生命科学学院

落继先:女,硕士生导师,山西朔州人;

联系电话:15698553399;

E-mail:luojx@sxu.edu.cn

研究方向:肺癌和白血病的转移、浸润机制研究与药物研发;

教育背景

2005.9-2010.7 东北师范大学 生命科学学院 遗传与细胞研究所 硕博连读

2000.9-2004.7 长春师范学院 生命科学学院 学士

研究背景

2014.1-至今    山西大学 生命科学学院 副教授

2012.11-2014.3  德州大学医学分部(University of Texas Medical Branch) 访问学者

2011.11-2015.2 山西大学生物学博士后

2010.7-2013.12 山西大学 生命科学学院 讲师

主持的科研项目

[1] RhoGDI2的磷酸化在SDF-1引起的β1整合素介导的Jurkat细胞迁移过程中的作用研究,国家自然科学青年基金(31401216),25万;镉影响华溪蟹蜕皮过程的分子机制,国家基金委博士后基金面上基金(2012M510773),5万;

[2] RhoGDI2在PSGL-1信号通路中的作用及机制研究,教育部新教师基金(20121401120006),4万;

[3] SDF-1在白血病细胞浸润中的作用机制研究,山西省回国留学人员科研资助项目(2017-012),2万;

[4] Rho在T细胞急性白血病中的作用机制研究和其在白血病靶向治疗中的应用,山西省自然科学基金面上项目(201901D111010),5万;

参与的科研项目

[1] 糖尿病人肿瘤易感性增高的生物学原理和分子机制以及肿瘤预防方法的研究,山西省自然科学基金面上项目(201601D011066),3万,排名第二;

[2] 2015细胞中心体扩增的分子机制的研究,山西省国际科技合作计划项目(2015081034),10万,排名第三;

[3] 重组华溪蟹金属硫蛋白在AUMO融合系统中的表达及其功能研究(高等学校博士学科点专项科研基金博导类(20111401110010),6万,排名第三;

[4] PI3K激酶在L-选择素和PSGL-1介导的白细胞起始黏附过程中的信号转导作用研究,国家自然科学基金面上基金(30971498),35万,排名第三。

相关领域的第一作者论文

[1] Jixian Luo, Dan Wei,Dingyun Li, Lan Wang. Nitric oxide functions in stromal cell-derived factor-1-induced cytoskeleton changes and the migration of Jurkat cells.Oncology Letters.16(5):6685-6690. 2018.

[2] Jixian Luo. PI3K is a linker between L-selectin and PSGL-1 Signaling to IL-18 transcriptional activation at the promoter level.Inflammation. 41(2):555-561.2018.

[3] Jixian Luo, Dingyun Li, Dan Wei, Xiaoguang Wang, Lan Wang, Xianlu Zeng. RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.Molecular and Cellular Biochemistry.436(1-2):13-21. 2017.

[4] Jixian Luo, Koa Hosoki, Attila Bacsi, Zsolt Radak, Muralidhar L. Hegde, Sanjiv Sur, Tapas K. Hazra, Allan R. Brasier, Xueqing Ba, Istvan Boldogh. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free Radical Biology & Medicine. 73:430-8. 2014.

[5] Jixian Luo, Sihui Pei, Weixin Jing, Enmin Zou, Lan Wang. Cadmium inhibits molting of the freshwater crab Sinopotamon henanense by reducing the hemolymph ecdysteroid content and the activities of chitinase and N-acetyl-β-glucosaminidase in the epidermis. Comparative biochemistry and physiology. Part C. 169:1-6. 2014.

[6] Jixian Luo, Tingshuang Xu, Chunfeng Li, Xueqing Ba, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediated lymphocyte adhesion to VCAM-1. The International Journal of Biochemistry & Cell Biology. 45(12): 2764-2773. 2013.  

[7] Jixian Luo, Chunfeng Li, Tingshuang Xu, Wenai Liu, Xueqing Ba, Xiaoguang Wang, Xianlu Zeng.  PI3K is involved in β1 integrin clustering by PSGL-1 and promotes β1 integrin-mediated Jurkat cell adhesion to fibronectin. Molecular and Cellular Biochemistry. 385(1-2): 287-295. 2013.

[8] Jixian Luo, Tingshuang Xu, Xiaoguang Wang, Xue Feng, Xueqing Ba, Xianlu Zeng. PI3K is involved in L-selectin- and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly. Journal of Cellular. Biochemistry. 110 (4): 910-919. 2010.

参与发表的SCI论文

[1] Yongquan Li, Huizhen Yang, Na Liu, Jixian Luo, Qian Wang, Lan Wang. Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana. PLoS One. 10(2):e0117037. 2015.

[2] Xueqing Ba, Attila Bacsi, Jixian Luo, Leopoldo Aguilera-Aguirre, Xianlu Zeng, Zsolt Radak, Allan R. Brasier, Istvan Boldogh.8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. Journal of Immunology. 192(5):2384-94. 2014.

[3] Tingshuang Xu, Wenai Liu, Jixian Luo, Chunfeng Li, Xueqing Ba, Khamal Kwesi Ampah, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. PLoS One. 8(12):e81807. 2013.

[4] Wenwen Lei, Lan Wang, Dongmei Liu, Tuan Xu, Jixian Luo. Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. Chemosphere. 84(5):689-94.2011.

[5] Lingling Cui, Cuixia Chen, Ting Xu, Juechao Zhang, Xin Shang, Jixian Luo, Liang Chen, Xueqing Ba, Xianlu Zeng. c-Abl Kinase is required for β-2 integrin-medated neutrophil adhesion. Journal of Immunology. 182 (5): 3233-3242. 2009.

[6] Ting Xu, Liang Chen, Xin Shang, Lingling Cui, Jixian Luo, Cuixia Chen, Xueqing Ba and Xianlu Zeng. Critical role of Lck in L-selectin signaling induced by sulfatides engagement. Journal of Leukocyte Biology. 84 (8): 1192-1201. 2008.

[7] Cuixia Chen, Xin Shang, Lingling Cui, Ting Xu, Jixian Luo, Xueqing Ba, Xianlu Zeng. L-selectin ligation-induced CSF-1 genetranscription is regulated by AP-1 in a c-Abl kinase-dependent manner. Human Immunology. 69 (8): 501-509. 2008.

[8] Cuixia Chen, Xin Shang, Ting Xu, Lingling Cui, Jixian Luo, Xueqing Ba, Shui Hao and Xianlu Zeng. c-Abl is required for the signaling transduction induced by L-selectin ligation. European Journal of Immunology. 37 (11): 3246-3258. 2007.

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